WHAT IS GLUTATHIONE?
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Inhibitory mechanism of melanin synthesis by glutathione
Glutathione dose dependently inhibited melanin synthesis in the reaction of tyrosinase and L-DOPA. The inhibition of melanin synthesis was recovered by increasing the concentration of L-DOPA, but not recovered by increasing tyrosinase. Glutathione inhibited the binding between tyrosinase and L-DOPA. Although the synthesized melanin was aggregated within 1 h, the aggregation was inhibited by the addition of glutathione. These results indicate that glutathione inhibits the synthesis and agglutination of melanin by interrupting the function of L-DOPA.
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Skin Health
This is the inner layer of the skin called dermis and the outer surface which is visible in our eyes is the epidermis. The primary determinant of variability in human skin color is the melanin and melanocyte is a cell that synthesizes it. L-glutathione, main component, starts the lightening process in the dermis working its way out to the surface.
This is the point where the metabolic pathway of melanin begins. As you see in the diagram GSH(reduced glutathione) intervenes the metabolism. There are certain kinds of compounds that inhibits the tyrosinase activity and L-glutathione is one of them.
This is the point where the metabolic pathway of melanin begins. As you see in the diagram GSH(reduced glutathione) intervenes the metabolism. There are certain kinds of compounds that inhibits the tyrosinase activity and L-glutathione is one of them
